Additionally, CDR1as contributes to Alzheimer's disease by binding to miR-7, reducing the ability of miR-7 thus upregulate ubiquitin-conjugating enzyme E2 A (UBE2A), a protein that decreases rapidly in Alzheimer's disease and other neurological diseases (58, 59) (Table 1). The gene discussed is UBE2A; the disease is early-onset autosomal dominant Alzheimer disease.