EWSR1 and neoplasm: Additionally, the intron-containing circRNAs produced by CUT-like homeobox 1 (CUX1), can bind to EWS RNA-binding protein 1 (EWSR1) to promote MYC-associated zinc finger protein (MAZ) transactivation and leads to transcriptional changes in CUX1 as well as other genes associated with tumor progression (35).