MAPT and Alzheimer disease: 2D cell culture models of FAD and SAD based on patient-derived iPSCs have been shown to resemble some features of AD pathophysiology, such as intracellular accumulation of soluble Aβ species, aggregation of insoluble Aβ species, and tau hyperphosphorylation (Kondo et al., 2013; Freude et al., 2014).