Several limitations accompany the implementation of transgenic mice in elucidating the molecular mechanisms underlying AD pathophysiology, such as the inability to capture tau pathology and the development of AD features early in life (Andorfer et al., 2003; Kitazawa et al., 2012; Sasaguri et al., 2017; Gerakis and Hetz, 2019). This evidence concerns the gene MAPT and Alzheimer disease.