MAPT and Alzheimer disease: Additionally, in contrast to published data not supporting a pivotal role of amyloids in AD manifestation (Takahashi et al., 2015; Kametani and Hasegawa, 2018), the authors showed that inhibition of Aβ species limited tau hyperphosphorylation only after Aβ reduction was observed, suggesting that Aβ accumulation-driven phenotypes in AD may emerge prior to tauopathy (Raja et al., 2016).