The missense mutation F145S in the Fibroblast Growth Factor 14 (FGF14) causes SCA27 in humans through a dominant negative effect (van Swieten et al., 2003; Brusse et al., 2006), and FGF14 ablation induces ataxia in mice (Wang et al., 2002). Here, FGF14 is linked to spinocerebellar ataxia type 27.