BRCA1/2 frequencies in French Canadians appear, however, to be higher than in outbred populations: Genotyping of 1220 breast cancer cases unselected for family history, age, or ethnicity found 0.7% and 1.3% of BRCA1 and BRCA2 variant heterozygotes, respectively21. The gene discussed is BRCA1; the disease is breast carcinoma.