Rubattu et al. performed an F2 intercross study and identified linkage to stroke centered on a microsatellite marker located ~11 Mb from the Stim1 mutation [12] and created congenic lines to support the presence of a stroke susceptibility locus in SHR-A3 encompassing ~50 Mb and including the location of Stim1 [33]. Here, STIM1 is linked to stroke disorder.