Indeed, tumors in African Americans, compared with Caucasians, had distinct mutations in the DNA repairome, a higher rate of somatic mutations overall, and major disparities in genes such as XPC, ATR, and MBD4. If validated, these data can be used to select important biomarkers of PCa progression, mortality and racial disparities, and to guide therapeutic options. This evidence concerns the gene ATR and posterior cortical atrophy.