The most frequently mutated DNA repairome genes in African Americans tumors were EXO1 (89%), ATR (73%), POLQ (68% of PCa), NEIL3 (47%), ERCC6 (42%), BRCA2 (52.6%), BRCA1 (52%), XPC (47%), JAG1 (47%), RPA1 (42%), ATM (42%), POLE (36%), and LIG1 (26%) (Fig. 2a). This evidence concerns the gene BRCA1 and posterior cortical atrophy.