While overexpression of CREB1 is well described in a number of cancer types including solid (e.g. melanoma, glioblastoma) and hematopoietic tumors (e.g. acute myeloid leukemia)17,18, CREB1 expression and the underlying control mechanisms are only poorly analyzed in RCC. The gene discussed is CREB1; the disease is renal cell carcinoma.