In response to the oAβ challenge, there were also significant downregulations observed in several proteins, including the neurodegenerative disease (ND)-related protein TDP-43 (fold change 0.4, p = 0.038) and COPI retrograde trafficking protein coatomer subunit delta (fold change 0.2, p = 0.026) were observed in response to oAβ. This evidence concerns the gene TARDBP and neurodegenerative disease.