Relative PD-L1 expression in the Parsortix was 0.48 (range: 0–2.39) in HD, 0.71 (range: 0–2.48) in PD-L1 negative HNSCC patients and 5.94 (range: 3.07–11.63) in PD-L1 positive HNSCC patients. Here, CD274 is linked to head and neck squamous cell carcinoma.