AR and prostate cancer: Notably, the CM of THP1-derived TAMs significantly promoted the migration, invasion, EMT, and the PCSCs subpopulation of both the androgen receptor (AR)-negative prostate cancer cells (PC3 and DU145) and the AR-positive prostate cancer cells (LnCaP and VCaP), while CCL5 neutralizing antibody (NA) could partly abrogate that (Fig. 3c–e and Supplementary Fig. 1).