This is referred to as T2 asthma and is driven by CD4+ T-helper (Th) 2 lymphocytes, mast cells and possibly innate lymphoid cells (ILC2) which secrete interleukin (IL)-4, IL-5 and IL-13 leading to eosinophilic inflammation and production of immunoglobulin (Ig)E from B cells [3, 4]. The gene discussed is IGHE; the disease is asthma.