SHANK3 and Angelman syndrome: These are often observed in neurons derived from individuals with idiopathic forms of ASD [112, 116, 167], as well as from individuals with genetically defined forms of ASD such as SHANK3 [127, 130], 16p11.2 deletion and duplication [125], Angelman syndrome [121], Dup15q syndrome [122], NRXN1 mutations [133, 135, 137], and PTCHD1-AS [140].