Glioma secreted cytokines (e.g., CSF-1, MCP-3, CX3CL1, SDF-1, and GM-CSF) that are especially known to be involved in the recruitment of microglial cells and could be responsible (in part) for the observed changes in gene expression, with EV-GFP uptake being a mere side-effect [3]. This evidence concerns the gene CSF1 and central nervous system cancer.