To comprehensively explore the association between TP53 mutation and survival of patients with EGFR- TKIs or ALK-TKIs treatments, subgroup analyses were performed based on type of targeted drugs (EGFR-TKIs or ALK-TKIs) (Fig. 3a,b); histopathological type of tumor (ADC or all NSCLC subtypes) (Fig. 4a,b); treatment line of targeted therapy (first line or all lines) (Fig. 5a,b). This evidence concerns the gene TP53 and neoplasm.