The animal study has shown that blocking the ion channel activity of SARS-CoV E protein by deletion of associated genes leads to the reduction of the edema and the level of inflammasome-activated interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF) all of which have an important role in the progression of ARDS [22]. The gene discussed is IL6; the disease is acute respiratory distress syndrome.