Although most patients were cosensitized to both Ara h 2 and Ara h 6, levels of Ara h 6–specific IgE were generally lower in patients with peanut allergy, and the degree of IgE inhibition to both allergens was higher following preincubation with Ara h 2 than with Ara h 6, suggesting that Ara h 2 is the dominant allergen. Here, IGHE is linked to peanut allergic reaction.