Only 1 individual with peanut allergy in our cohort was monosensitized to Ara h 6 on the basis of initial ImmunoCAP testing; however, genuine monosensitization is dubitable following subsequent ImmunoCAP ISAC analyses that reported sensitization to both Ara h 2 and Ara h 6, with higher levels of Ara h 6–specific IgE than Ara h 2–specific IgE. This evidence concerns the gene IGHE and peanut allergic reaction.