Comparing with this national data, the current cross-sectional study found that much higher prevalence of depression (48.3%, 95%CI: 46.9%-49.7%), anxiety (22.6%, 95%CI: 21.4%-23.8%) and CDA (19.4%, 95%CI: 18.3%-20.6%) during COVID-19 outbroke in Wuhan, China. The gene discussed is CDA; the disease is COVID-19.