However, our data suggesting that low AnxA6 and high GRF2 expression levels are associated with poorer RFS of basal-like breast cancer patients compared to high AnxA6 and low GRF2 expression levels led us to speculate that the ratio of GRF2 to AnxA6 can delineate rapidly growing from invasive TNBCs. Here, RASGRF2 is linked to breast cancer.