While statistical significance was slightly reduced due to the decrease in the number of events (33 breast cancer deaths compared to 55 deaths from any cause), the effects estimates for all three genes remained stable compared to the overall survival analysis [CLCA2 HR = 1.66, SPIC HR = 1.52, MIR4311 HR = 1.52]. The gene discussed is CLCA2; the disease is breast carcinoma.