Regarding lipid profiles, we found that SLE patients with NTIS had a substantially higher TG (1.9 ± 1.3 mmol/L vs. 1.46 ± 0.8 mmol/L; p < 0.01), TC (4.9 ± 1.9 mmol/L vs. 4.3 ± 0.9 mmol/L; p < 0.01), LDL (2.8 ± 1.4 mmol/L vs. 2.3 ± 0.7 mmol/L; p < 0.01), apolipoprotein B (ApoB) (1.1 ± 0.5 g/L vs. 0.8 ± 0.2 g/L; p < 0.001), ApoB/apolipoprotein A1 (ApoA1) (1.1 ± 0.03 vs. 0.7 ± 0.02; p < 0.001), as well as considerably lower HDL (1.0 ± 0.4 mmol/L vs. 1.2 ± 0.6 mmol/L; p < 0.01) levels compared with patients in the euthyroid group. The gene discussed is APOA1; the disease is systemic lupus erythematosus.