Direct relationships focusing on interaction networks observed from all data sources were considered in the analysis, and demonstrated 10 network affected including the top networks affected among responders that were associated with Cellular Development, Cellular Growth and Proliferation, Organismal Development (Score = 49), with 14 molecules involved in breast cancer (ABCB1, ALK, BCL2, CCND1, CDK1, DNMT3B, FOXA1, HIST2H2BE, ITPR1, JAK1, MDM2, MFN2, RUNX3, USP6NL, Fig 4a). Here, MDM2 is linked to breast cancer.