Among non-responders, the top network out of 20 networks affected was associated with Tissue Morphology, Organismal Development, Embryonic Development (Score = 25) with 23 molecules involved in breast cancer (ADRA1B, ALOX5, BCL2L2, BHLHE40, CCND1, CD40LG, CDKN1A, GPR65, HDAC2, IL2, JARID2, KRT18, KRT19, MAPK1, MECOM, NFATC1, NR3C1, PRDM16, RAD21, RPS6KA2, SKI, TK1, TWIST2, Fig 4b). This evidence concerns the gene MECOM and breast cancer.