In a mouse model of intestinal cancer driven by loss of the adenomatous polyposis coli (Apc) gene, activation of mechanistic target of rapamycin complex 1 (mTORC1) drives increased translational elongation; however, this can be successfully targeted with rapamycin to inhibit intestinal tumorigenesis (Faller et al., 2015). The gene discussed is APC; the disease is intestinal cancer.