We investigated SLIT3 and NETRIN1 (NTN1), which are key ligands of the SLIT/ROBO and NETRIN/DCC/UNC signaling pathways, and are regulators of neuron maturation and neurite outgrowth but are also playing roles in angiogenesis, lung morphogenesis, mammary gland development and cancer progression involving processes such as cell migration, cell interaction and cell adhesion (Bashaw and Klein, 2010; Blockus and Chédotal, 2016; Lai Wing Sun et al., 2011; Seiradake et al., 2016). Here, DCC is linked to cancer.