For example, lncRNA MALAT1 modulates gastric cancer cell autophagy via sequestrating miR‐23b‐3p.30 LncRNA HOXB‐AS3A encodes peptide to restrain cell growth in colon cancer growth.31 LncRNA IGFBP4‐1 is overexpressed and promotes lung cancer cell proliferation by reprogramming energy metabolism.32 This study first identified a novel lncRNA up‐regulated in LUSC based on data analysis in GEPIA and circlncRNAnet. This evidence concerns the gene MALAT1 and malignant colon neoplasm.