For instance, lncRNA UICLM acts as a ceRNA to regulate ZEB2 expression and trigger tumour growth and liver metastasis by sponging miRNA‐215 in colorectal cancer.41 LncRNA CRNDE acts as a ceRNA to up‐regulate IRS1 expression and facilitate cell proliferation and metastasis through sponging miR‐384 in pancreatic cancer.42 LncRNA RP11‐436H11.5 acts as a ceRNA to up‐regulate BCL‐W expression and promote the proliferation and invasion via sponging miR‐335‐5p in renal cell carcinoma.30 Herein, we first validated that miR‐450b‐5p and miR‐515‐5p combined with LINC00519 and YAP1 in LUSC. This evidence concerns the gene IRS1 and colorectal cancer.