Recent work shows that PD‐L1 inside tumor cells can regulate ovarian cancer and melanoma cell growth, pathogenesis and autophagy,19 promote bladder cancer proliferation, glycolysis,15 and be involved in lung cancer chemoresistance.20 However, the function of PD‐L1 in aspirin‐resisted lung cancer remains unclear. This evidence concerns the gene CD274 and lung carcinoma.