Increased levels of high sensitive C-reactive protein (hsCRP), TNFα and its soluble receptors, IL-6, IL-1, IL-8, IL-18 were found in different chronic conditions such as atherosclerosis, cardiovascular disease, chronic heart failure (CHF), diabetes, chronic obstructive pulmonary disease, chronic kidney disease, and cancer. The gene discussed is TNF; the disease is congestive heart failure.