The work of Orlic et al. has documented the efficacy of murine lineage-negative c-kit-positive (Linˉ c-kit+) bone marrow (BM) cell transplantation for repairing experimentally induced myocardial infarct, resulting in clinical applications for patients with acute myocardial infarct (AMI) [2]. This evidence concerns the gene KIT and acute myocardial infarction.