REN and COVID-19: Correct evaluation of this double burden is challenged by three gaps in our knowledge: (1) the unknown confounding effect of age on mortality of CVD/COVID-19 patients, (2) the not fully understood effects of COVID-19 on the cardiovascular system, and (3) how antihypertensive medications targeting the renin–angiotensin system (RAS) might be associated with the severity of and survival to COVID-19 in CVD patients.