Different Tau inclusions also vary in size and morphology, leading to the hypothesis that Tauopathies are characterized by unique Tau strains formed by a specific combination of post-translational modifications on the Tau-splicing isoforms (Clavaguera et al., 2013; Guo and Lee, 2014; Boluda et al., 2015; Brettschneider et al., 2015; Goedert and Spillantini, 2017; Reilly et al., 2017). This evidence concerns the gene MAPT and tauopathy.