Previously, we demonstrated that human Tau is phosphorylated at the same epitopes as found in AD brain when expressed in the yeast S. cerevisiae and that, also in this model, hyperphosphorylation triggers conformational changes in Tau thereby leading to a small fraction of sarkosyl insoluble material (Vandebroek et al., 2005, 2006; Vanhelmont et al., 2010). Here, MAPT is linked to Alzheimer disease.