Since phosphorylation also determines the propensity of Tau to assemble into filaments and neurofibrillary tangles, which is the main characteristic of a large group of neurodegenerative disorders known as Tauopathies (Buee et al., 2000; Sergeant et al., 2008), it is evident that conformational changes in Tau are closely linked to its pathobiology. This evidence concerns the gene MAPT and tauopathy.