PIN1 and leukemia: For example, Pin1 associates with the pThr254-Pro motif of transcription factor NF-κB p65 subunit, leading to the increased protein stability of p65 and enhanced transcriptional activity of NF-κB in various cancers, including leukemia, lymphomas, and glioblastoma (Ryo et al., 2003; Atkinson et al., 2009).