Pin1 isomerizes both Ser910-phosphorylated FAK and Ser571-phosphorylated PTP-PEST to enhance the interaction between PTP-PEST and FAK, leading to the dephosphorylation of FAK Tyr397 by PTP-PEST and the promotion of migration, invasion, and metastasis of Ras-related tumor cells (Zheng et al., 2009, 2011). This evidence concerns the gene PIN1 and neoplasm.