In detail, Pin1 isomerizes p53-RS phosphorylated by CDK4 in the G1/S phase and enhances nuclear localization of p53-RS, resulting in a p53-RS-c-Myc interaction and an elevated c-Myc-dependent rDNA transcription key for ribosomal biogenesis, which promotes cell cycle progression and cell growth of hepatocellular carcinoma (Liao et al., 2017). This evidence concerns the gene TP53 and hepatocellular carcinoma.