In detail, Pin1 isomerizes p53-RS phosphorylated by CDK4 in the G1/S phase and enhances nuclear localization of p53-RS, resulting in a p53-RS-c-Myc interaction and an elevated c-Myc-dependent rDNA transcription key for ribosomal biogenesis, which promotes cell cycle progression and cell growth of hepatocellular carcinoma (Liao et al., 2017). The gene discussed is PIN1; the disease is hepatocellular carcinoma.