PIN1 and neoplasm: Substitution of BRD4 with Pin1-binding-defective BRD4-T204A mutant reduces BRD4 stability, which attenuates BRD4-mediated gene expression and suppresses cell proliferation, migration, invasion, and tumor formation, suggesting the positive correlation of Pin1 function and BRD4 stability in gastric cancer cells (Hu et al., 2017).