As Table 3 shows, the ORs (95% CI) were 1.09 (1.04–1.13), 1.72 (1.23–2.43), and 1.04 (1.02–1.07) in GSE8401, GSE15605, and GSE46517 datasets, respectively (Table 3), indicating that IRS was the risk factor for melanoma metastasis. The gene discussed is IARS1; the disease is melanoma.