CREB1 and infection: For example, NF-κB acts cooperatively with CREB and AP-1 during lytic infection of fibroblasts, and synergizes with CREB to activate the enhancer during reactivation of latently infected N-Tera2 cells (Lashmit et al., 2009; Caposio et al., 2010; Liu X. et al., 2010; Isern et al., 2011; Yuan et al., 2015).