In this regard, gastric tumor tissues overexpressing LINGO2 shows elevated expression of the angiogenic marker pVEGFR2 and a blood vessel marker CD34, meanwhile the silencing of LINGO2 in Human Umbilical Vein Endothelial Cells (HUVEC) cells results in inhibition of tube formation, suggesting the involvement of positive-LINGO2 CSCs in angiogenesis (59). The gene discussed is LINGO2; the disease is gastric neoplasm.