Considering that hnRNPA1 can perform the variable splicing of PKM mRNA in order to increase the ratio of PKM2/PKM1 to promote cancer (13, 14, 16), the interaction with hnRNPA1 to splice the mRNA of PKM may be an important mechanism of SNHG6 that is involved in the metabolic process of CRC. The gene discussed is PKM; the disease is cancer.