HNRNPA1 and colorectal carcinoma: Given that hnRNPA1 could perform variable splicing of the precursor mRNA of PKM to increase the proportion of PKM2/PKM1 (13, 14, 16), we assumed that it was possible for SNHG6 to interact with hnRNPA1 as well as induce hnRNPA1 to target the precursor mRNA of PKM and participate in the variable splicing process, which would promote the occurrence and the development of CRC.