HNRNPA1 and colorectal carcinoma: In this study, through the results of a joint analysis conducted on SNHG6 using ChIRP–MS and bioinformatics methods, it was found that SNHG6 could interact with hnRNPA1 and specifically target the 3′UTR of the PKM precursor mRNA as well as induce hnRNPA1 to specifically splice the PKM precursor mRNA, which resulted in an increase of the ratio of PKM2/PKM1, which in turn enhanced the aerobic glycolysis process of CRC cells and promoted the development of CRC (Figure 10D).