INPPL1 and breast carcinoma: It has been demonstrated that, in breast cancer, the activation of PI3Kα or PI3Kβ is implicated in invadopodia formation and matrix degradation, following integrin signaling, by increasing the levels of PI(3,4,5)P3 used by SHIP2 as substrate to produce PI(3,4)P2 (59, 60).