Interestingly, PTEN/INPP4B loss in non-transformed cells (Mcf10a) potentiates EGF-dependent AKT phosphorylation and invadopodia formation, although it has opposite effects in breast and prostate cancer cells, reducing AKT activation possibly by inhibiting class I PI3K signaling (35). The gene discussed is INPP4B; the disease is prostate cancer.