CYP3A4 and hepatocellular carcinoma: Both CYP2E1 and CYP3A4, as members of the cytochrome P450 family which contributes to drug metabolism, lipid synthesis and homeostasis (Manikandan & Nagini, 2018), have been reported to be less expressed in HCC (Chen et al., 2014; Hu et al., 2019).