Downregulated AOX1 (Figs. 7K, 7L), CYP2E1 (Figs. 7O, 7P), and CYP3A4 (Figs. 7Q, 7R) were highly expressed in normal liver tissue but undetectable or expressed at low levels in HCC. The gene discussed is CYP3A4; the disease is hepatocellular carcinoma.