Ning et al. (2018) demonstrated that parkin mediated mitochondrial autophagy was upregulated post-HIRI, leading to decreased hepatocyte death. However, parkin deficiency elevates HIRI by decreasing mitochondrial autophagy and increasing apoptosis. Bhogal et al. (2018) found that autophagy within LEC is reduced accompanying IRI increased cell death. Li et al. (2018a), Li et al. (2018b), Li et al., (2018c) and Li et al. (2018d) demonstrated that impairing mitophagy contributed to aggravation of hepatic ischemia-reperfusion injury in aging mice. The gene discussed is PRKN; the disease is ischemia reperfusion injury.