In addition, GLS expression in TNBC is significantly correlated with a low level of tumor-infiltrating lymphocytes (TILs), suggesting a metabolic competition between cancer cells and TILs in the tumor microenvironment, where active consumption of intercellular glutamine by GLS-overexpressing TNBC cells deprives TILs of glutamine and hinders their proliferation34 (Figure 2). Here, GLS is linked to cancer.