PTGS2 and melanoma: In this review, we propose an updated overview regarding the role of COX-2 in the progression of melanoma, focused on 1) the relevance of COX-2 as a potential prognostic factor; 2) the potential beneficial role of COX-2 as a therapeutic ­target in melanoma; 3) the use of COX-2 inhibitors, focusing mainly on celecoxib, as adjuvants for current oncological therapies.