NO is produced by endothelial nitric oxide synthase (eNOS) catalyzed oxidation of l-arginine in vascular endothelial cells, and it has pleiotropic effects including maintaining cardiovascular homeostasis, regulating vasodilation, promoting ECs growth, maintaining ECs integrity, inhibiting platelet and leukocyte adhesion, aggregation, inhibiting SMCs proliferation and preventing atherosclerosis [11–13]. This evidence concerns the gene NOS3 and atherosclerosis.