IFNs are also able to elicit inhibition of angiogenesis by downregulating the expression of potent angiogenic factors in endothelial and stromal cells, including IL-8, platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF), and in tumor cells, such as fibroblast growth factors (FGFs) (68–72). The gene discussed is VEGFA; the disease is neoplasm.