CD8A and neoplasm: Indirect/unspecific immunoregulatory effects of IFNs encompass activation of dendritic cells to cross-present tumor antigens to T cells (78), promotion of full CD8+ maturation necessary for them to elicit their cytotoxic effects (29, 79, 80), prevention of the proliferation of T regulatory cells, as well as enhancement of T helper cell function (81, 82) and promotion of macrophage polarization toward an M1-like pro-inflammatory state instead of the M2 pro-tumoral state (83), thus eluding their immunosuppressive effect (83, 84), amongst other mechanisms (85).