At the level of tumor cell survival, IFNs can induce tumor cell apoptosis through various mechanisms, such as the TRAIL pathway (59, 60), via CD95/Fas (61, 62) and the activation of pro-apoptotic members of the Bcl-2 family [reviewed by Kotredes and Gamero (63)]. This evidence concerns the gene TNFSF10 and neoplasm.