- Inhibition of CXCL12-induced chemotaxis of CLL cells - ↑ CLL migration underneath a confluent layer of BMSCs - release of CXCL12 from cell-surface-bound GAGs - competition with heparin for binding to CXCL12 - Sensitization of CLL cells toward cytotoxic agents in BMSC cocultures. The gene discussed is CXCL12; the disease is B-cell chronic lymphocytic leukemia.