Among the five variants of the LOX family, lysyl oxidase-like 2 (LOXL2) has been identified as the primary enzyme promoting network formation of collagen and elastin fibers during human and experimental liver fibrosis of various etiologies (3, 6, 8–10) as well as HCC metastasis (11). The gene discussed is LOXL2; the disease is Hepatic fibrosis.