Patients with diverse AID such as psoriasis (Pso), psoriatic arthritis (PsA), RA, Crohn's disease (CD), ulcerative colitis (UC), ankylosing spondylitis (AS), juvenile idiopathic arthritis (JIA), but not MS, have benefitted from TNF-α inhibition (7). This evidence concerns the gene TNF and rheumatoid arthritis.