The current set of targeted PIDDs includes ADA deficiency (ADA) (39, 40), Dedicator of cytokinesis 8 (DOCK8) deficiency (6, 41), X-Linked Chronic Granulomatous disease (XL-CGD) (42, 43), Wiskott-Aldrich Syndrome (WAS) (44, 45), and X-Linked Agammaglobulinemia (XLA) (46, 47). This evidence concerns the gene DOCK8 and isolated agammaglobulinemia.