We noted that several of the downregulated genes were involved in migration: Ccr1 and Ccr5 are inflammatory chemokine receptors, the latter previously shown to direct Tregs to inflamed tissues (50, 51), while Adam8 influences cell migration through proteolytic cleavage of PSGL-1 and is also associated with invasiveness in cancer (52, 53). The gene discussed is SELPLG; the disease is cancer.