AKT1 and kidney disorder: The anti-inflammatory effects of ARS have been widely recognized, including repression of nuclear factor-κB (NF-κB), toll-like receptors (TLRs), signal transducer and activator of transcription (STAT), and phosphatidylinositol-3-kinase (PI3K)/protein kinase B (AKT) activity (Aldieri et al., 2003; Ho et al., 2014; Shi et al., 2015), which are key factors mediating immune-inflammatory response and are associated with kidney disease progression (Ruiz-Andres et al., 2016).