Our research combined with previous studies proved that VDR and YAP1 was extremely downregulated in cholestasis (Anakk et al., 2013; Gonzalez-Sanchez et al., 2017) and both VDR–/– mice and YAP1–/– mice were more sensitive to cholestasis-induced liver injury (Bai et al., 2012; Firrincieli et al., 2013). The gene discussed is YAP1; the disease is cholestasis.