APC and autism: In our β-cat cOE mice, heterozygous expression of this degradation resistant isoform led to β-cat increases, with total β-cat levels comparable to that of APC cKOs (One-way ANOVA F(3, 8) = 87.39, p < 0.001; Figure 1B), allowing us to assess the effects of similarly increased β-cat, in the presence vs. absence of APC, in causing autism relevant behavioral phenotypes.