Activating autophagy through cAMP-response element binding protein-regulated transcription coactivator (Crtc, also known as MTORC1) inhibition increases the degradation rate of the huntingtin protein (HTT) and ameliorates the neurodegeneration-like effects generated in mouse and fly models of Huntington’s disease (Ravikumar et al., 2004). Here, HTT is linked to juvenile Huntington disease.